Article

Diversity of motility gene signatures distinguishes commensal Clostridia that elicit divergent host immune responses

2025-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Adaptive immune responses to commensal flagellins are hallmarks of Crohn’s disease, but it is unclear whether flagellins themselves promote inflammation or whether flagellated commensals can also be colitogenic. Here, we show that the arrangement of motility loci and the diversity of encoded flagellins can separate flagellated gut-derived Clostridia into at least 2 functionally distinct groups....

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Literature Corpus work: 7ed3def8-da18-54c0-a687-ea0b157978cb
DOI: 10.1101/2025.07.18.665615

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