Article
A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin.
PloS one - 1 Jan 2013
Sheridan Jared, Mack David R, Amre Devendra K, Israel David M, Cherkasov Artem, Li Huifang, Grimard Guy, Steiner Theodore S
Abstract excerpt
BACKGROUND AND OBJECTIVES: Although numerous studies have implicated TLR5, or its ligands, bacterial flagellins, in the pathogenesis of Crohn's disease (CD), genome-wide association studies (GWAS) have not reported associations with the TLR5 gene. We aimed to examine potential CD-associated TLR5 variants and assess whether they modified inflammatory responses to bacterial flagellins. METHODS AND PRINCIPAL...
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