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Article

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses.

Scientific reports - 20 Jul 2020

Sánez Tähtisalo Heini, Ruotsalainen Sanni, Mars Nina, Porthan Kimmo, Oikarinen Lasse, Virolainen Juha, Fyhrquist Frej, Ripatti Samuli, Kontula Kimmo K, Hiltunen Timo P

Abstract excerpt

Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32686723
DOI: 10.1038/s41598-020-68878-3
PMCID: PMC7371738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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