Article
Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.
The pharmacogenomics journal - 1 Feb 2016
Sanada H, Yoneda M, Yatabe J, Williams S M, Bartlett J, White M J, Gordon L N, Felder R A, Eisner G M, Armando I, Jose P A
Abstract excerpt
Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations. This study replicated the association of GRK4 variants, including GRK4(142V), with human essential hypertension in a Japanese population (n=588; hypertensive, n=486 normotensive controls) and determined whether the presence of GRK4 variants predicted the blood pressure (BP) response to...
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