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GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2026

Ebinger Joseph E, Kauko Anni, Vaura Felix, Hage Paul, Sundström Johan, Joung Sandy Y, Cheng Susan, Niiranen Teemu J

Abstract excerpt

BACKGROUND: Resistant hypertension (RH), in which blood pressure remains elevated on ≥3 medications or controlled on ≥4 medications, increases the risk of adverse cardiovascular events nearly 50% more than primary hypertension. We sought to identify genetic drivers of RH in a reliable and generalizable manner. METHODS: We utilized FinnGen (discovery) and UKBB (UK Biobank, replication) data sets to identify...

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Identifiers

PMID: 41404655
DOI: 10.1161/HYPERTENSIONAHA.125.25719
PMCID: PMC12714304

Genes

KCNK3
CASZ1
EVX1
LSP1
WNT2B
CRP

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