Article
DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia.
Genome research - 1 May 2021
Giacopelli Brian, Wang Min, Cleary Ada, Wu Yue-Zhong, Schultz Anna Reister, Schmutz Maximilian, Blachly James S, Eisfeld Ann-Kathrin, Mundy-Bosse Bethany, Vosberg Sebastian, Greif Philipp A, Claus Rainer, Bullinger Lars, Garzon Ramiro, Coombes Kevin R, Bloomfield Clara D, Druker Brian J, Tyner Jeffrey W, Byrd John C, Oakes Christopher C
Abstract excerpt
Acute myeloid leukemia (AML) is a molecularly complex disease characterized by heterogeneous tumor genetic profiles and involving numerous pathogenic mechanisms and pathways. Integration of molecular data types across multiple patient cohorts may advance current genetic approaches for improved subclassification and understanding of the biology of the disease. Here, we analyzed genome-wide DNA methylation in 649...
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