Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML

24 Jul 2025

Abstract excerpt

BACKGROUND: Comprehensive analysis of single-cell transcriptome and chromatin accessibility will contribute to interpret the heterogeneity of acute myeloid leukemia (AML). We hypothesize that integrating single-cell transcriptomic and chromatin accessibility landscapes underlying t(8;21) AML will provide valuable insights into its heterogeneous cellular properties and gene regulatory programs. METHODS: Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40707954
DOI: 10.1186/s12967-025-06659-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AMLPMID 40707954Read ↗

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukemiaSemantic proximity Read ↗

Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AMLSemantic proximity Read ↗

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.Semantic proximity Read ↗

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia.Semantic proximity Read ↗

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AMLSemantic proximity Read ↗

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming.Semantic proximity Read ↗

Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulatorsSemantic proximity Read ↗

Decoding the genetic symphony: Profiling protein-coding and long noncoding RNA expression in T-acute lymphoblastic leukemia for clinical insightsSemantic proximity Read ↗

A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemiaSemantic proximity Read ↗

Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities.Semantic proximity Read ↗

Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML.Semantic proximity Read ↗

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.