[Investigation of a causal relationship between mtDNA mutations and a mitochondrial respiratory dysfunction in premature aging mice].

Abstract excerpt

The mitochondrial theory of aging has been proposed, which suggests that the accumulations of multiple in mtDNA with age induce decreased mitochondrial respiratory function, ultimately leading to aging. This hypothesis is widely accepted because mtDNA mutator mice (Polgmut/mut mice) with a homozygous proofreading-deficient mutation in Polg gene accumulate random point mutations in mtDNA, resulting in...

Topics

Join the communities discussing this publication.

• Aging
• Aging, Premature
• DNA-Directed DNA Polymerase
• DNA, Mitochondrial
• DNA Polymerase gamma