Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of Notch signaling pathway attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats post-myocardial infarction.

American journal of physiology. Cell physiology - 1 Jan 2016

Yin Jie, Hu Hesheng, Li Xiaolu, Xue Mei, Cheng Wenjuan, Wang Ye, Xuan Yongli, Li Xinran, Yang Na, Shi Yugen, Yan Suhua

Abstract excerpt

Inflammation-dominated sympathetic sprouting adjacent to the necrotic region following myocardial infarction (MI) has been implicated in the etiology of arrhythmias resulting in sudden cardiac death; however, the mechanisms responsible remain to be elucidated. Although being a key immune mediator, the role of Notch has yet to be explored. We investigated whether Notch regulates macrophage responses to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiac Pacing, Artificial

Share to Dipeptides

Share to Interleukin-1beta

Share to Nerve Growth Factor

Share to Receptor, Notch1

Share to Sympathetic Nervous System

Source

Identifiers

PMID: 26491050
DOI: 10.1152/ajpcell.00163.2015

Genes

NGF
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Notch signaling pathway attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats post-myocardial infarction.PMID 26491050Read ↗

Atorvastatin attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats postmyocardial infarction.Semantic proximity Read ↗

Increase in cholinergic modulation with pyridostigmine induces anti-inflammatory cell recruitment soon after acute myocardial infarction in rats.Semantic proximity Read ↗

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction.Semantic proximity Read ↗

Nicorandil regulates the macrophage skewing and ameliorates myofibroblasts by inhibition of RhoA/Rho-kinase signalling in infarcted rats.Semantic proximity Read ↗

Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarctionSemantic proximity Read ↗

Sympathetic neurons exacerbate atherosclerosis by modulating macrophage function via the NPY/Y1R axis.Semantic proximity Read ↗

CD226 deletion improves post-infarction healing via modulating macrophage polarization in mice.Semantic proximity Read ↗

Cholinergic Polarization of Human MacrophagesSemantic proximity Read ↗

Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation.Semantic proximity Read ↗

Combined Checkpoint Inhibition Amplifies Post-Infarction Injury via T Cell-Mediated Macrophage ActivationSemantic proximity Read ↗

Macrophages and the Survival of Cardiomyocytes After Myocardial Infarction.Semantic proximity Read ↗

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.