Article
Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis.
Journal of thrombosis and haemostasis : JTH - 1 Jan 2015
Kooijman S, Meurs I, van der Stoep M, Habets K L, Lammers B, Berbée J F P, Havekes L M, van Eck M, Romijn J A, Korporaal S J A, Rensen P C N
Abstract excerpt
BACKGROUND: The autonomic nervous system attenuates inflammation through activation of the α7 nicotinic acetylcholine receptor (α7nAChR), a pathway termed the cholinergic anti-inflammatory reflex. Interestingly, α7nAChR is expressed on immune cells and platelets, both of which play a crucial role in the development of atherosclerosis. OBJECTIVE: To investigate the role of hematopoietic α7nAChR in inflammation and...
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