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Article

Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.

Nature communications - 27 Jun 2026

Zhang Yixin, Dai Jinglan, Gu Pan, Zhao Yang, Christiani David C, Chen Feng, Shen Sipeng

Abstract excerpt

Polygenic risk scores (PRSs) quantify genetic susceptibilities, yet ancestry imbalance in genome-wide association studies (GWASs) limits the accuracy of monoracial PRSs in non-European populations. Here, we perform a multiancestry GWAS meta-analysis for lung cancer (76,953 cases and 1,886,372 controls), identifying 87 conditionally independent genome-wide significant loci, including two unreported cytobands. We...

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Identifiers

PMID: 42364979
DOI: 10.1038/s41467-026-74964-3
PMCID: PMC13454572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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