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Article

Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.

Nature genetics - 1 Feb 2026

He Yixuan, Lu Wenhan, Jee Yon Ho, Shih Mu-Yi, Wang Ying, Tsuo Kristin, Qian David C, Diao James A, Huang Hailiang, Patel Chirag J, Byun Jinyoung, Pasaniuc Bogdan, Atkinson Elizabeth G, Amos Christopher I, Feng Yen-Chen Anne, Moll Matthew, Cho Michael H, Martin Alicia R

Abstract excerpt

While respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma share many risk factors, most studies investigate them in isolation and in predominantly European-ancestry populations. Here, we conducted the most powerful multi-trait and multi-ancestry genetic analysis of respiratory diseases and auxiliary traits to date, identifying 25 new loci associated with lung function in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41565855
DOI: 10.1038/s41588-025-02470-1
PMCID: PMC13284852

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