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Article

The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank.

British journal of cancer - 1 Mar 2026

Galal Bayan, Dennis Joe, Antoniou Antonis C, Harrison Hannah

Abstract excerpt

BACKGROUND: Risk-stratified lung cancer screening programs identify high-risk individuals who use tobacco but do not account for underlying genetic susceptibility. Many polygenic scores (PGS) have been developed for lung cancer, but it is unclear which, if any, are suitable for identifying high-risk individuals in the general population. METHODS: We used a systematic review to identify published lung cancer PGS,...

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Identifiers

PMID: 41507563
DOI: 10.1038/s41416-025-03330-9
PMCID: PMC12960659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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