Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model.

doi:10.1158/0008-5472.CAN-20-1237

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Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model.

Cancer research - 15 Mar 2021

Hung Rayjean J, Warkentin Matthew T, Brhane Yonathan, Chatterjee Nilanjan, Christiani David C, Landi Maria Teresa, Caporaso Neil E, Liu Geoffrey, Johansson Mattias, Albanes Demetrius, Marchand Loic Le, Tardon Adonina, Rennert Gad, Bojesen Stig E, Chen Chu, Field John K, Kiemeney Lambertus A, Lazarus Philip, Zienolddiny Shanbeth, Lam Stephen, Andrew Angeline S, Arnold Susanne M, Aldrich Melinda C, Bickeböller Heike, Risch Angela, Schabath Matthew B, McKay James D, Brennan Paul, Amos Christopher I

Abstract excerpt

Lung cancer is the leading cause of cancer-related death globally. An improved risk stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we assessed whether individual's genetic background has clinical utility for risk stratification in the context of LDCT screening. On the basis of 13,119 patients with lung cancer and 10,008 controls with European ancestry in the International...

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PMID: 33472890
DOI: 10.1158/0008-5472.CAN-20-1237
PMCID: PMC7969419

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