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Article

Identifying shared polygenic risk across cancers.

PLoS genetics - 1 Sept 2026

Hu Jiaqi, Muheyati Maiyier, Xu Leqi, DeWan Andrew, Zhao Hongyu

Abstract excerpt

BACKGROUND: Shared genetic susceptibility across cancers has been reported but is generally modest at the genome-wide level. Whether such shared polygenic risk exhibits structured convergence at regional or functional levels remains unclear. We investigated shared genetic risk across cancers by integrating local genetic correlation analyses with cross-cancer polygenic risk score (PRS) associations. METHODS: We...

Read the complete abstract on PubMed

Topics

Humans
Genetic Risk Score
Multifactorial Inheritance
Genome-Wide Association Study
Genetic Predisposition to Disease
Neoplasms
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Genetic Pleiotropy

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Open in PubMed Open full text

Identifiers

PMID: 42758802
DOI: 10.1371/journal.pgen.1012308
PMCID: PMC13600620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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