The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis.

doi:10.1155/2019/1409069

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Article

The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis.

Disease markers - 1 Jan 2019

De Silvestri A, Capittini C, Mallucci G, Bergamaschi R, Rebuffi C, Pasi A, Martinetti M, Tinelli C

Abstract excerpt

Multiple Sclerosis (MS) displays a heterogeneous clinical onset and progression, which are mostly unpredictable, but demyelination of the central nervous system (CNS) leads to substantial deficits of sensory, motor, autonomic, and neurocognitive functions. Considering all genetic studies on MS, including the advanced genome-wide association studies, the risk linked to HLA alleles remains the highest among other...

Topics

Alleles
Animals
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-DQ beta-Chains
HLA-DRB1 Chains
Humans
Multiple Sclerosis
Risk Factors

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Identifiers

PMID: 31781296
DOI: 10.1155/2019/1409069
PMCID: PMC6875418

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