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The genetic architecture of multiple sclerosis in 2026: From susceptibility to disease progression.

Revue neurologique - 1 May 2026

Bourguiba-Hachemi S, Paris J, Gourraud P-A, Vince N

Abstract excerpt

The genetics of multiple sclerosis (MS) has advanced dramatically through the combined impact of high-throughput genotyping, large biobank resources, worldwide collaborations, and powerful computational analyses. Over the past two decades, genome-wide association studies (GWAS) have significantly reshaped our understanding of the genetic architecture of complex multifactorial diseases such as MS. The number of MS...

Topics

Humans
Multiple Sclerosis
Genetic Predisposition to Disease
Disease Progression
Genome-Wide Association Study
Major Histocompatibility Complex

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41934071
DOI: 10.1016/j.neurol.2026.03.006

Genes

CYP27B1
NLRP1
PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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