Article
Risk HLA Variants Affect the T-Cell Repertoire in Multiple Sclerosis
15 Feb 2023
Abstract excerpt
Background and Objectives The major histocompatibility complex (MHC) locus has a predominant role in the genetic predisposition to multiple sclerosis (MS), with 32 associations found to be involved. We aimed to investigate the impact of MHC MS-risk alleles on T-cell repertoire in patients with MS. Methods We studied 161 untreated patients with relapsing-remitting MS for whom Class I and II human leukocyte antigen...