Article

Elf1 promotes Rad26’s interaction with lesion-arrested Pol II for transcription-coupled repair

2023-09-10

Abstract excerpt

Transcription-coupled nucleotide excision repair (TC-NER) is a highly conserved DNA repair pathway that removes bulky lesions in the transcribed genome. Cockayne syndrome B protein (CSB), or its yeast ortholog Rad26, has been known for decades to play important roles in the lesion-recognition steps of TC-NER. Another conserved protein ELOF1, or its yeast ortholog Elf1, was recently identified as a core transcripti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f88af7c5-83d0-5cfb-a647-5625301893b8
DOI: 10.1101/2023.09.08.556893

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elf1 promotes Rad26’s interaction with lesion-arrested Pol II for transcription-coupled repairDOI 10.1101/2023.09.08.556893Read

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26.Semantic proximity Read

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesionsSemantic proximity Read

Prolonged stalling of RNA Polymerase II at DNA damage explains phenotypical differences between Cockayne and UV-sensitive syndromesSemantic proximity Read

XPF mediates 3’ flap processing for FEN1-independent Okazaki fragment maturationSemantic proximity Read

ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer TherapySemantic proximity Read

Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for ActivationSemantic proximity Read

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation.Semantic proximity Read

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.Semantic proximity Read

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repairSemantic proximity Read

Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.Semantic proximity Read

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read