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Article

Evolution of drug-resistant viral populations during interruption of antiretroviral therapy.

Journal of virology - 1 Jul 2011

Wang Dongning, Hicks Charles B, Goswami Neela D, Tafoya Emi, Ribeiro Ruy M, Cai Fangping, Perelson Alan S, Gao Feng

Abstract excerpt

Analysis of a large number of HIV-1 genomes at multiple time points after antiretroviral treatment (ART) interruption allows determination of the evolution of drug-resistant viruses and viral fitness in vivo in the absence of drug selection pressure. Using a parallel allele-specific sequencing (PASS) assay, potential primary drug-resistant mutations in five individual patients were studied by analyzing over...

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Identifiers

PMID: 21490094
DOI: 10.1128/JVI.02389-10
PMCID: PMC3126484

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Source receipt: pubmed, retrieved 7 Sept 2026.

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