Endonuclease-Assisted Selective Exponential Amplification for Ultrasensitive Enrichment and Detection of Low-Abundance Mutant Alleles in Lung Cancer.

doi:10.1016/j.jmoldx.2026.05.008

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Article

Endonuclease-Assisted Selective Exponential Amplification for Ultrasensitive Enrichment and Detection of Low-Abundance Mutant Alleles in Lung Cancer.

The Journal of molecular diagnostics : JMD - 1 Sept 2026

Li Pei, Lv Bao, Zhang Liyi, Xu Xiaoling, Zhang Zhanfang, Li Weijian, Zhang Tao, Miao Xinyu, Pan Xiaoguang, Luo Yonglun, Mao Weimin, Lu Hongyang, Song Jinzhao

Abstract excerpt

Lung cancer is one of the most prevalent and lethal malignancies worldwide. Despite recent advancements in precision medicine, early detection and therapeutic monitoring of lung cancer remain challenging. Herein, an endonuclease-assisted selective exponential amplification (ESEA) platform is presented that selectively depletes wild-type alleles through programmable endonuclease digestion (CRISPR-Cas or...