Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression.

Abstract excerpt

Approximately 15% of non-small cell lung cancer cases are associated with a mutation in the epidermal growth factor receptor (EGFR) gene, which plays a critical role in tumor progression. With the goal of treating mutated EGFR-mediated lung cancer, we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to discriminate between the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to A549 Cells
• Share to CRISPR-Cas Systems
• Share to Gene Targeting