Article
Identification of new overlapping and disease-specific genetic risk factors for rheumatoid arthritis and radiographic axial spondyloarthritis: a meta-analysis of three large European populations and functional characterization.
Frontiers in immunology - 1 Jan 2026
Cabrera-Serrano Antonio José, Carretero-Fernández María, Pérez-Rojo Begoña, Ter Horst Rob, Cañadas-Garre Marisa, Canhão Helena, Quartuccio Luca, Sorensen Signe B, Glintborg Bente, Filipescu Ileana, Pérez-Pampin Eva, Conesa-Zamora Pablo, Swierkot Jerzy, den Broeder Alfons A, de Vita Salvatore, Brix Petersen Eva Rabing, Li Yang, Coenen Marieke J H, Bogunia-Kubik Katarzyna, Andersen Vibeke, Fonseca João Eurico, Lund Hetland Merete, López Nevot Miguel Ángel, López-Medina Clementina, Reyes-Zurita Fernando Jesús, Netea Mihai G, Escudero Alejandro, Cáliz Rafael, Collantes-Estévez Eduardo, Sánchez-Maldonado José Manuel, Sainz Juan
Abstract excerpt
Introduction: This study conducted a meta-analysis across three large European cohorts (UKBB, FinnGen, and REPAIR), including 12,660 rheumatoid arthritis (RA) cases, 2,446 radiographic axial spondyloarthritis (r-axSpA) cases, and over 530,000 shared controls. Methods: Ten independent SNPs in CARMIL1, GRM4, ITPR3, PRSS16, ZNF322, HTT, IKZF1, MANEA, and MGAM2 were analyzed, and functional characterization was...
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