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Article

Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.

Annals of the rheumatic diseases - 1 Mar 2021

López-Isac Elena, Smith Samantha L, Marion Miranda C, Wood Abigail, Sudman Marc, Yarwood Annie, Shi Chenfu, Gaddi Vasanthi Priyadarshini, Martin Paul, Prahalad Sampath, Eyre Stephen, Orozco Gisela, Morris Andrew P, Langefeld Carl D, Thompson Susan D, Thomson Wendy, Bowes John

Abstract excerpt

OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. Our understanding of the genetic risk factors for this disease is limited due to low disease prevalence and extensive clinical heterogeneity. The objective of this research is to identify novel JIA susceptibility variants and link these variants to target genes, which is essential to facilitate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33106285
DOI: 10.1136/annrheumdis-2020-218481
PMCID: PMC7892389

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