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Article

Integrated multi-omics strategies for identifying novel therapies in psoriasis.

Bioinformatics (Oxford, England) - 1 Jun 2026

Si Shucheng, Wang Xiaoxiao, Zhan Siyan

Abstract excerpt

MOTIVATION: Psoriasis is a chronic, immune-mediated disorder with an unmet need for effective treatments. To systematically prioritize therapeutic targets, we integrated proteome-wide Mendelian randomization (MR) with expression validation in blood/skin, genetic susceptibility analysis, differential gene expression (DGE) from bulk and single-cell RNA sequencing (scRNA-seq), colocalization, pathway enrichment, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42209436
DOI: 10.1093/bioinformatics/btag347
PMCID: PMC13275128

Genes

IL2RA
RARRES2
ASF1A
CD8A
CTF1
DBI
ICAM1
IL7R
MMP12
SGSH
A2ML1
FAP
IL23A
NFKB1
TIMD4
XCL2
B3GNT2
COMP
DAPK2
GCA
ICAM5
IL12A
PRSS53
UBLCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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