Article
Single-cell transcriptomic mendelian randomization and co-localization reveal immune-mediated regulatory mechanisms and drug targets in atopic dermatitis.
International immunopharmacology - 15 Apr 2026
Zhou Kunli, Li Weixing, Zou Ying, Cai Liangqi, Xu Qiuyun, Tong Zequn, Zhao XiaoYan, Gong Ting, Ji Chao, Cheng Bo, Xiang Niu
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin condition with increasing prevalence; however, the underlying immune mechanisms remain poorly understood. Precision therapeutics have shown promise, yet significant unmet clinical needs remain. Single-cell expression quantitative trait loci (sc-eQTL) combined with genome-wide association studies (GWAS) and mendelian randomization (MR) can provide...
Topics
- Dermatitis, Atopic
- Humans
- Genome-Wide Association Study
- Mendelian Randomization Analysis
- Quantitative Trait Loci
- Transcriptome
- Single-Cell Analysis
- Genetic Predisposition to Disease
- Single-Cell Gene Expression Analysis