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Article

Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study.

Journal of translational medicine - 20 Dec 2024

Dai Lingyu, Xia Lan, Su Guannan, Gao Yu, Jiang Qingyan, Yang Peizeng

Abstract excerpt

BACKGROUND: To investigate the associations of methylation, expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) with ankylosing spondylitis (AS) and find out genetically supported drug targets for AS. METHODS: The summary-data-based Mendelian randomization (SMR) and Bayesian co-localization analysis were used to assess the potential causality between AS and relevant genes. The GWAS data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39707330
DOI: 10.1186/s12967-024-05925-x
PMCID: PMC11662797

Genes

B3GNT2
ERAP1
FCGR2A
TNFRSF1A
AIF1
APOM
FCGR2B
IL12B
TNXB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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