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Article

Integrated Genomic and Transcriptomic Analysis Reveals the Genetic Basis and Causal Association Between Obesity and Atrial Fibrillation.

Diabetes, obesity & metabolism - 1 Sept 2026

Wu Xize, Xu Guorui, Wang Ruiying, Cai Qicheng, Kang Jian, Ruan Minglin, Ren Jiaqi, Li Yue, Gong Lihong

Abstract excerpt

BACKGROUND: Observational studies have shown that obesity is associated with an increased risk of atrial fibrillation (AF), but the underlying genetic mechanisms and direction of causality remain unclear. This study aims to systematically investigate the genetic associations, direction of causality and key pleiotropic genes linking obesity and AF by integrating large-scale genome-wide association study (GWAS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42304163
DOI: 10.1111/dom.71016
PMCID: PMC13448850

Genes

NFATC2IP
NUCKS1
PCCB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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