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Article

SLIT2 and ANGPTL3 as putative mediators linking obesity to atrial fibrillation: A Mendelian randomization study.

Medicine - 3 Jul 2026

Wu Yanping, Peng Ying, Zhang Qing, Xu Wen, Li Qianyuan, Chen Xiaodi, Lv Zhiyang

Abstract excerpt

The observational association between obesity and atrial fibrillation has been well-established. However, its causal mediators underlying this association remain unclear. This study aimed to investigate the causal relationship between body mass index (BMI), as well as potential mediating factors underlying this association, using Mendelian randomization (MR). Genetically predicted BMI was significantly associated...

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Share to Angiopoietin-Like Protein 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42410793
DOI: 10.1097/MD.0000000000049568
PMCID: PMC13336997

Genes

ANGPTL3
SLIT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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