Article
Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization.
Circulation - 21 Feb 2017
Chatterjee Neal A, Giulianini Franco, Geelhoed Bastiaan, Lunetta Kathryn L, Misialek Jeffrey R, Niemeijer Maartje N, Rienstra Michiel, Rose Lynda M, Smith Albert V, Arking Dan E, Ellinor Patrick T, Heeringa Jan, Lin Honghuang, Lubitz Steven A, Soliman Elsayed Z, Verweij Niek, Alonso Alvaro, Benjamin Emelia J, Gudnason Vilmundur, Stricker Bruno H C, Van Der Harst Pim, Chasman Daniel I, Albert Christine M
Abstract excerpt
BACKGROUND: Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the causal association between BMI and AF by using genetic predictors of BMI. METHODS: We identified 51 646...
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