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Article

Polystyrene nanoplastics elicit early mitochondria-associated phenotypic, metabolic, and functional responses in human hepatocytes.

Environment international - 1 Aug 2026

Särndahl Eva, Bergman Emma, Kotlyar Oleksandr, Karlsson Patrik, Zetzsche Jonas, Wu Rongrong, Engwall Magnus, Hyötyläinen Tuulia, Alijagic Andi

Abstract excerpt

Nanoplastics have recently been detected in human liver tissue, raising concerns about their potential impact on liver function. However, early hepatocyte responses associated with nanoplastics exposure remain poorly understood. Here, we combined high-throughput Cell Painting-based phenomics, untargeted metabolomics, and Seahorse mitochondrial functional assay to investigate the effects of 100 nm polystyrene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42302456
DOI: 10.1016/j.envint.2026.110370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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