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1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies

19 Jun 2024

Abstract excerpt

The immortalised human hepatocellular HepG2 cell line is commonly used for toxicology studies as an alternative to animal testing due to its characteristic liver-distinctive functions. However, little is known about the baseline metabolic changes within these cells upon toxin exposure. We have applied 1H Nuclear Magnetic Resonance (NMR) spectroscopy to characterise the biochemical composition of HepG2 cells at...

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PMID: 38906200
DOI: 10.1016/j.tiv.2024.105881

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