Article
Single-cell metabolomics: analytical and biological perspectives.
Science (New York, N.Y.) - 6 Dec 2013
Zenobi R
Abstract excerpt
There is currently much interest in broad molecular profiling of single cells; a cell's metabolome-its full complement of small-molecule metabolites-is a direct indicator of phenotypic diversity of single cells and a nearly immediate readout of how cells react to environmental influences. However, the metabolome is very difficult to measure at the single-cell level because of rapid metabolic dynamics, the...
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