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Cell Painting phenomics reveals size-dependent phenotypic responses to titanium dioxide nanoparticles in HepG2 cells.

Toxicology - 1 Nov 2026

Boustani Adil, Ounoughi Abir, Zetzsche Jonas, Karlsson Patrik, Kotlyar Oleksandr, Särndahl Eva, Engwall Magnus, Scherbak Nikolai, Alijagic Andi

Abstract excerpt

Titanium dioxide nanoparticles (TiO₂NPs) are widely produced engineered nanomaterials with ongoing human exposure through consumer and occupational uses. Conventional in vitro assays often focus on cytotoxicity and may therefore overlook early or sublethal cellular perturbations. Here, we applied Cell Painting-based phenomics to resolve size-dependent sub-lethal phenotypic signatures of TiO2NP exposure in human...

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Identifiers

PMID: 42218974
DOI: 10.1016/j.tox.2026.154512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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