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Article

Endothelial tenascin signaling preserves VSMCs contractile phenotype in the human arterial wall in type II diabetes mellitus.

Journal of translational medicine - 29 Apr 2026

Liu Xuan, Yang Chen, Pei Liying, Muniasamy Umamaheswari, Chaykun Gleb, Ong Mei Shan, Ihsan Mario Octavianus, Gurung Rijan, Liu Boxiang, Sorokin Vitaly A

Abstract excerpt

BACKGROUND: Phenotypic switching of vascular smooth muscle cells (VSMCs) is a hallmark of coronary artery disease (CAD). How type 2 diabetes mellitus (T2DM), a major risk factor for cardiovascular complications, reshapes these VSMCs states remains poorly defined. METHODS: Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, high-dimensional weighted gene coexpression network analysis (hdWGCNA), and...

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Share to Arteries
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

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Share to Muscle, Smooth, Vascular

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Source

Open in PubMed Open full text

Identifiers

PMID: 42057014
DOI: 10.1186/s12967-026-08095-0
PMCID: PMC13134109

Genes

CAD
ITGA8
TNXB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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