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Article

SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm.

The Journal of clinical investigation - 25 Jun 2024

Song Tianyu, Zhao Shuang, Luo Shanshan, Chen Chuansheng, Liu Xingeng, Wu Xiaoqi, Sun Zhongxu, Cao Jiawei, Wang Ziyu, Wang Yineng, Yu Bo, Zhang Zhiren, Du Xiaolong, Li Xiaoqiang, Han Zhijian, Chen Hongshan, Chen Feng, Wang Liansheng, Wang Hong, Sun Kangyun, Han Yi, Xie Liping, Ji Yong

Abstract excerpt

Aortic aneurysm is a life-threatening disease with limited interventions that is closely related to vascular smooth muscle cell (VSMC) phenotypic switching. SLC44A2, a member of the solute carrier series 44 (SLC44) family, remains undercharacterized in the context of cardiovascular diseases. Venn diagram analysis based on microarray and single-cell RNA sequencing identified SLC44A2 as a major regulator of VSMC...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Abdominal

Share to Membrane Glycoproteins

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Share to Mice, Knockout, ApoE

Share to Muscle, Smooth, Vascular

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Source

Open in PubMed Open full text

Identifiers

PMID: 38916960
DOI: 10.1172/JCI173690
PMCID: PMC11324303

Genes

SLC44A2
ITGB3
NRP1
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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