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Article

Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm.

Cell communication and signaling : CCS - 15 May 2023

Cao Genmao, Xuan Xuezhen, Li Yaling, Hu Jie, Zhang Ruijing, Jin Haijiang, Dong Honglin

Abstract excerpt

BACKGROUND AND OBJECTIVES: Phenotypic switching in vascular smooth muscle cells (VSMCs) has been linked to aortic aneurysm, but the phenotypic landscape in aortic aneurysm is poorly understood. The present study aimed to analyse the phenotypic landscape, phenotypic differentiation trajectory, and potential functions of various VSMCs phenotypes in aortic aneurysm. METHODS: Single-cell sequencing data of 12 aortic...

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Share to Aortic Aneurysm
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Share to Sequence Analysis, RNA

Share to Single-cell and spatial transcriptomics

Source

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Identifiers

PMID: 37189183
DOI: 10.1186/s12964-023-01120-5
PMCID: PMC10184349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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