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Article

LINC01278 Sponges miR-500b-5p to Regulate the Expression of ACTG2 to Control Phenotypic Switching in Human Vascular Smooth Muscle Cells During Aortic Dissection.

Journal of the American Heart Association - 4 May 2021

Wang Weitie, Liu Qing, Wang Yong, Piao Hulin, Zhu Zhicheng, Li Dan, Wang Tiance, Liu Kexiang

Abstract excerpt

Background Phenotypic switching in vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of aortic dissection (AD). This study aims to explore the potential mechanisms of linc01278 during VSMC phenotypic switching. Methods and Results Twelve samples (6 AD and 6 control) were used for lncRNA, microRNA, and mRNA microarray analysis. We integrated the mRNA microarray data set with GSE52093 to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33910387
DOI: 10.1161/JAHA.120.018062
PMCID: PMC8200748

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