Article
Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors.
Nature genetics - 1 Jun 2026
Fujii Masayuki, Abeto Naoko, Kishimoto Shotaro, Shiraishi Kouya, Hashimoto Taiki, Hiraoka Nobuyoshi, Nonaka Satoru, Kojima Motohiro, Matano Mami, Takahashi Sirirat, Colozza Gabriele, Koo Bon-Kyoung, Yatabe Yasushi, Kato Motohiko, Sato Toshiro, Sekine Shigeki
Abstract excerpt
The majority of intestinal tumors harbor mutations in canonical Wnt pathway genes such as APC, whereas the lack of such alterations in a subset of tumors implies alternative tumorigenic routes. Here we identify recurrent in-frame deletion in COPA, frequently co-occurring with USP9X-truncating mutation, in small intestinal adenoma and adenocarcinoma. Patient-derived and CRISPR-engineered small intestinal organoids...
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