Article
CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes
12 Jul 2019
Abstract excerpt
Significance Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Genome sequencing studies have provided comprehensive CRC genomic datasets; however, functional validation for most candidate CRC driver genes has not been performed. Here, we describe a platform for functionally validating CRC driver genes that utilizes CRISPR-Cas9 in mouse intestinal tumor organoids and human CRC-derived...
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