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Article

USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.

Cell reports - 17 Oct 2017

Novellasdemunt Laura, Foglizzo Valentina, Cuadrado Laura, Antas Pedro, Kucharska Anna, Encheva Vesela, Snijders Ambrosius P, Li Vivian S W

Abstract excerpt

The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We find that the β-catenin inhibitory domain (CID) in APC represents the threshold for pathological levels of Wnt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29045831
DOI: 10.1016/j.celrep.2017.09.072
PMCID: PMC5656747

Genes

APC
USP7

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