Article

USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

2022-09-23

Abstract excerpt

Truncating mutation of the tumor suppressor gene adenomatous polyposis coli (APC) is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its essential role in normal stem cell maintenance. We have previously shown that the deubiquitinating enzyme USP7 is a tumor-specific WNT activator in APC-tru...

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Literature Corpus work: f87ca535-7da0-5b55-a990-96a8d9fbd7f3
DOI: 10.1101/2022.09.22.508986

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