Article
Dose-Related Mutagenic and Clastogenic Effects of Benzo[b]fluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay.
Environmental science & technology - 10 Dec 2024
Schuster David M, LeBlanc Danielle P M, Zhou Gu, Meier Matthew J, Dodge Annette E, White Paul A, Long Alexandra S, Williams Andrew, Hobbs Cheryl, Diesing Alex, Smith-Roe Stephanie L, Salk Jesse J, Marchetti Francesco, Yauk Carole L
Abstract excerpt
Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that originate from the incomplete combustion of organic materials. We investigated the clastogenicity and mutagenicity of benzo[b]fluoranthene (BbF), one of 16 priority PAHs, in MutaMouse males after a 28 day oral exposure. BbF causes robust dose-dependent increases in micronucleus frequency in peripheral blood, indicative of chromosome...
Topics
- Animals
- Mice
- Mutagens
- Micronucleus Tests
- Male
- Mutation
- Fluorenes
- Dose-Response Relationship, Drug
- DNA Damage