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Article

Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung.

Toxicological sciences : an official journal of the Society of Toxicology - 2 Mar 2026

Faske Jennifer B, Gong Binsheng, LeBlanc Danielle P, Funk Juergen, Zhou Gu, Kehm Sabrina, White Paul A, Robison Timothy, Zeller Andreas, Yauk Carole L, Marchetti Francesco, Parsons Barbara L

Abstract excerpt

Clonal expansion (CE) of cells carrying cancer driver mutations (CDMs) is being developed as a biomarker of cancer risk. CE in lung of MutaMouse males treated with 0, 6.25, 12.5, and 25 mg/kg/d benzo[b]fluoranthene (B[b]F) by gavage for 90 and 180 d was assessed by CarcSeq. DNA regions encompassing mouse correlates of human hotspot CDMs were PCR amplified, attaching 18-base unique molecular identifiers (UMIs)...

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Identifiers

PMID: 41859812
DOI: 10.1093/toxsci/kfag030
PMCID: PMC13011165

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