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G-quadruplex forming regions in <i>GCK</i> and <i>TM6SF2</i> are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients

2024-03-26

Abstract excerpt

The alarming increase in global rates of metabolic diseases (MetDs) and their association with cancer risk renders them a considerable burden on our society. The interplay of environmental and genetic factors in causing MetDs may be reflected in DNA methylation patterns, particularly at non-canonical (non-B) DNA structures, such as G-quadruplexes (G4s) or R-loops. To gain insight into the mechanisms of MetD progre...

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Literature Corpus work
0066e117-d3b3-5543-9281-b7b439d60018
DOI
10.1101/2024.03.21.585382
Open publication

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G-quadruplex forming regions in <i>GCK</i> and <i>TM6SF2</i> are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patientsDOI 10.1101/2024.03.21.585382
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