Article

SNPs associated with Metabolic Disorders Disrupt Structural Properties of DNA G-Quadruplexes in Regulatory Regions relevant during Tumor Development

2025-07-18

Abstract excerpt

<title>Abstract</title> Background. The global prevalence of metabolic diseases (MetDs) is constantly rising and is associated with an increased risk of cancer development. Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) linked to MetDs, some of which occur in genes also implicated in tumorigenesis. G-quadruplexes (G4s) are non-canonical DNA secondary structure...

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Literature Corpus work: c7ee50b8-4367-5f5b-afa6-b16985e0933b
DOI: 10.21203/rs.3.rs-7128220/v1

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