Article

The Impact of Non-coding G-quadruplex Variants on Human Traits and Disease Susceptibility

2026-06-01

Abstract excerpt

Non-coding variants are important contributors to human traits and diseases but linking them to molecular mechanisms and phenotypes at scale remains challenging. G-quadruplexes (G4s) are four-stranded structures formed by guanine-rich sequences and have emerged as key functional elements within the non-coding genome. G4s are enriched in regulatory regions and can modulate gene expression at both the DNA and RNA le...

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Literature Corpus work: 43f032c8-5c7b-5d9f-9cdb-ea4d78a5d158
DOI: 10.64898/2026.05.29.26354456

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