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Article

PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.

Diabetes - 1 Aug 2020

Liu Longhua, Fan Lihong, Chan Michelle, Kraakman Michael J, Yang Jing, Fan Yong, Aaron Nicole, Wan Qianfen, Carrillo-Sepulveda Maria Alicia, Tall Alan R, Tabas Ira, Accili Domenico, Qiang Li

Abstract excerpt

Cardiovascular disease (CVD) is the leading cause of death in patients with diabetes, and tight glycemic control fails to reduce the risk of developing CVD. Thiazolidinediones (TZDs), a class of peroxisome proliferator-activated receptor γ (PPARγ) agonists, are potent insulin sensitizers with antiatherogenic properties, but their clinical use is limited by side effects. PPARγ deacetylation on two lysine residues...

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Identifiers

PMID: 32409492
DOI: 10.2337/db20-0217
PMCID: PMC7372079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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