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Article

Peroxisome proliferator-activated receptor δ improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching.

British journal of pharmacology - 1 Aug 2023

Lien Chih-Feng, Lin Chin-Sheng, Shyue Song-Kun, Hsieh Po-Shiuan, Chen Sy-Jou, Lin Yi-Tan, Chien Shu, Tsai Min-Chien

Abstract excerpt

BACKGROUND AND PURPOSE: Vascular smooth muscle cells (SMCs) undergo phenotypic switching during sustained inflammation, contributing to an unfavourable atherosclerotic plaque phenotype. PPARδ plays an important role in regulating SMC functions; however, its role in atherosclerotic plaque vulnerability remains unclear. Here, we explored the pathological roles of PPARδ in atherosclerotic plaque vulnerability in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Matrix Metalloproteinase 2

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

Identifiers

PMID: 36942453
DOI: 10.1111/bph.16074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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