Article

A Druggable G Protein Checkpoint in Cholesterol Efflux

2026-02-17

Abstract excerpt

<h4>SUMMARY</h4> Immunometabolic diseases such as obesity, fatty liver, and atherosclerosis arise when lipid-associated macrophages (LAMs) fail to resolve lipid overload via reverse cholesterol transport (RCT), the body’s sole pathway for lipid disposal. How RCT is restrained in disease remains unknown. Integrating systems modeling with human plaque transcriptomes, we identify LAM subpopulations associated with p...

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Literature Corpus work: 77077d55-06c2-5e80-b765-3c608194a291
DOI: 10.64898/2026.02.15.705962

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